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Anti-epidermal basement membrane and intracellular substance antibodies Typing (BPAg2/BP180, BPAg1/BP 230,desmoglein 1, desmoglein 3, Envoplakine and collagen VII) - serum

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Eurofins Biomnis code

BP180

Synonyms

  • BPAg1
  • Anti-NC16A antibodies
  • BP180
  • Anti-BPAG2 antibodies
  • BPAG2 - anti-antibodies
  • BPAG1 - anti-antibodies
  • Anti-desmoglein 1 antibodies
  • desmoglein 1
  • BP180 - anti-antibodies
  • BP230
  • Anti-desmoglein 3 antibodies
  • BP230 - anti-antibodies
  • Anti-BPAG1 antibodies
  • herpes gestationis factor
  • NC16A - anti-antibodies
  • desmoglein 3
  • pemphigus
  • bp180 - antibodies
  • pemphigoid

Clinic significance

Bullous skin diseases provoke cutaneous lesions (and/or mucous membrane lesions) that are not specific for the type of disease (pemphigus, pemphigoid etc.). They are characterised by the presence of auto antibodies that bind to the structures causing the cohesion of the epidermis or the dermal-epidermal junction. On sections of monkey oesophagus, within the tested areas (dermal-epidermal membrane or intracellular substance) we differentiate 2 major disease types (pemphigus or pemphigoid). Further testing can be carried-out to identify the antigenic targets and these antibodies and thus orient the diagnosis to a specific disease:

¿ The presence of anti-BP 230 and BP 180 antibodies is suggestive of pemphigoid
¿ The presence of anti-BP 180 antibodies is suggestive of benign mucous membrane pemphigoid or pemphigoid gestationis (e.g. herpes gestationis)
¿ The presence of anti-dermal basement membrane antibodies is suggestive of epidermolysis bullosa
¿ The presence of anti-desmoglein 1 antibodies is suggestive of pemphigus foliaceus
¿ The presence of anti-desmoglein 3 antibodies is suggestive of pemphigus chronicus

Prenalytics

  • 200 µL
  • serum (do not use 10 mL tube)
  • Refrigerated

Methodology

ELISA

Turnaround time

1 week


Pathologist(s) in charge
Biomnis Lyon
Specialty
Immunology
Contact(s)
Dr Alexia BARBRY
Dr Anne OVIZE
Phone(s)
+334 72 80 23 18
+334 72 80 73 05