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Anti-MPO antibodies - myeloperoxidase - Serum

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Eurofins Biomnis code

MPO

Synonyms

  • Anti-myeloperoxidase antibodies
  • Myeloperoxidase - anti-antibodies
  • MPO - anti-antibodies

Clinic significance

Anti-ANCA antibodies represent a recently developed marker which is very useful in the diagnosis of vasculitis. Three different staining patterns can be distinguished on polymorphonuclear cells fixed in ethanol and formaldehyde: cytoplasmic, perinuclear and X-ANCA. The two main specificities (myeloperoxidase and proteinase 3) are typed by Flow immunofluorometry. Perinuclear staining due to antinuclear antibodies can interfere with this screen. The presence of anti-PR3 antibodies correlates strongly with Wegener's granulomatosis whereas anti-MPO antibodies are found in crescentic glomerulonephritis and Shurg-Strauss syndrome (although this is less specific).

Prenalytics

  • 2 mL
  • Serum
  • Refrigerated

Further information


    Methodology

    ELISA

    Turnaround time

    4 days


    Pathologist(s) in charge
    Biomnis Paris
    Specialty
    Immunology
    Contact(s)
    Dr Laurence GUIS
    Dr Nihad MEKNACHE
    Phone(s)
    +331 49 59 15 01
    +331 49 59 63 40