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Erythrocyte pyruvate kinase - whole blood Refered Test

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Eurofins Biomnis code

PKE

Synonyms

  • Erythrocyte pyruvate kinase

Clinic significance

Congenital deficiency of pyruvate kinase (PK) activity in erythrocytes is an autosomal recessive trait which affects the anaerobic glycolysis pathway. Heterozygotes are usually asymptomatic but homozygotes are prone to chronic, medium-level hemolytic anemia with jaundice and variable splenomegaly. The condition can sometimes be complicated by pigmentary lithiasis and hemochromatosis.Reduced PK activity has been reported in certain kinds of acquired hemopathy including refractory anemia, erythropoietic disorders and acute granulocytic leukemia.
In children under one year of age, an erythrocyte PK assay cannot be interpreted due to unstabilised erythropoiesis and possible passage of erythroblasts into the bloodstream, especially in a haemolytic context.
To eliminate a PK deficiency, a parental sample for PK content is recommended. Enclose consent for possible genetic analysis.

Prenalytics

  • 5 mL
  • ACD whole blood
  • Refrigerated

Further information

  • 1 individual aliquot for this analysis.
  • do not collect before the age of 1 year
  • Dosage at a distance from any transfusion less than 3 months old

Specific equipment available

T16: ACD tube (provided on request)


Methodology

Spectrophotometry

Turnaround time

2 weeks


Pathologist(s) in charge
Refered Test
Specialty
Biochemistry
Contact(s)
Dr Dominique ENGERAND
Dr Isabelle PETIT
Phone(s)
+331 49 59 62 70
+331 49 59 16 72

Caption

Refered TestThe pre-analytical conditions and prices are defined on the basis of the requirements of the performing laboratory.