Eurofins Biomnis code

QANR

Synonyms

• Quantiferon test
• Quantiferon® TB Gold Plus
• Interferon Gamma Release Assays
• IGRA
• Interferon gamma production blood test

Clinic significance

After infection (by direct contact with saliva micro-droplets), M. tuberculosis multiplies in the body and is responsible for latent tuberculosis that will develop in 10% of cases into active tuberculosis disease. The latent form is diagnosed using the Mantoux test. The limits of this test have favoured the development of more specific blood tests (no cross reactivity with the BCG). Recommendations: Surveys around a case (age >5 years) 12 weeks after contact. Patients infected with HIV before treatment with anti-TNF - Hiring of migrant healthcare personnel < 15 years. The test is not indicated for diagnosing active tuberculosis disease.

Prenalytics

• plasma.
• Refrigerated

Further information

• [To be translated]
• Sampling to be carried out using the Quantiferon kit, to be ordered 3 days before the sample. Scrupulous compliance with the pre-analytical phase is required to ensure the quality of the result, in particular: - stir the tubes well before incubating 16 to24h at 36-38ºC - centrifuge before sending at +4ºC. There are no recommendations on centrifugation but the gel needs to be positioned between the cap and the plasma.

Specific equipment available

K4: Quantiferon sampling kit

Documents to download

• K4P-INTGB-Quantiferon®: sampling procedure

Methodology

Enzyme-immunoassay

Turnaround time

3 days