Eurofins Biomnis code

RSTR

Synonyms

• RsTf
• RST
• Soluble transferrin receptor

Clinic significance

The transferrin receptor mediates the internalization inside cells of iron-transferrin complexes from the blood. The soluble receptor is a truncated form of the functional, membrane-bound receptor. In normal subjects, the monomeric, truncated form accounts for 99% of the total amount of receptor (only 1% is functional).This test is useful in:- the diagnosis of iron deficiency associated with inflammation or infection (if ferritin levels are apparently normal or even high);??? Although ferritin measurements offer a good indication of iron status, ferritin is also an acute phase reactant. TSR shows little or no change in inflammation.- the diagnosis of functional iron deficiency in children, adolescents and athletes (in whom iron reserves and therefore ferritin levels are unreliable);- the early diagnosis of iron-deficient erythropoiesis (e.g. in pregnant women);- the differential diagnosis of anemia;- estimating the correct dose of erythropoietin (EPO) in patients with impaired kidney function;- to screen for EPO abuse: the concentration of soluble transferrin receptor rises by a factor of 50% in subjects who have taken EPO whereas it is not affected by 90 minute minutes of strenuous exercise.

Prenalytics

• 1 mL
• Serum
• Refrigerated

Methodology

Immuno turbidimetry

Turnaround time

2 days