Eurofins Biomnis code

TROPI

Clinic significance

Troponin is a protein complex that is found on the myofibrillar contractile apparatus and that regulates muscle contraction. It is composed of three subunits:
- Troponin C (TnC), which binds the calcium needed for muscle contraction;
- Troponin T (TnT), which binds the complex to the tropomysin filament and which represents a specific cardiac isoform;
- Troponin I (TnI), which inhibits contraction in the absence of calcium; it is the regulatory subunit. It regulates the ATPase activity of the actin-myosin complexes in muscle fibres. It has three isoforms: TnI_slow (slow-twitch skeletal muscle), TnI_fast (fast-twitch skeletal muscle), TnIc (cardiac).
TnIc is the fraction measured in routine testing. Its measurement is of value in:
- early and retrospective diagnosis of myocardial infarction (excellent cardiospecificity, 100%);
- covering the diagnostic window for CK-MB, total CK and LDH.
The diagnosis of myocardial infarction is confirmed by the change in cTnI values, which, in consideration of the clinical picture, makes it possible to rule out all other forms of myocardial disorder (severe myocarditis, mechanical myocardial contusions, etc.).

Prenalytics

• 1 mL
• serum
• FROZEN

Further information

• Attach the clinical data
• Centrifuge, decant and freeze for 30 min to 2 hours. Avoid glass tubes.

Methodology

CMIA

Turnaround time

2 days