List of dynamic tests
Purpose
To investigate suspected iron poisoning (haemochromatosis) or aluminium overload in subjects on haemodialysis.
Product
Desferal® 500 mg, Novartis Pharma SAS.
Dose
- To investigate iron poisoning: 500 mg injected IM.
- To investigate aluminium overload: slow perfusion of 5 mg/kg Desferal® in normal saline over a period of 30 minutes.
Protocol
1. Iron overload:
- Empty the bladder.
- IM injection of 500 mg Desferal®.
- Collect all urine for 6 hours after injection.
2. Aluminium overload in subjects on haemodialysis:
- Blood sample (heparinised tube) at T0 before the haemodialysis session.
- During the last hour of the session, perfuse the correct dose of Desferal® in normal saline.
- Take a second blood sample (heparinised tube) at T44 hours after the end of perfusion and before the next session.
Samples
Whole blood drawn into a special “Trace Elements” Vacutainer tube (supplied on request). Transport at + 4°C.
Assays
- Iron in the collected urine.
- Aluminium in the blood samples.