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Dexamethasone (rapid inhibition) test

List of dynamic tests
Purpose

Adrenocortical inhibition.
This test differentiates between different types of hyperadrenocorticism: obesity, Cushing’s syndrome, primary tumours.

Product

Dexamethasone (Dectancyl®, 0.5 mg tablets)

Dose

1 mg (2 Dectancyl® tablets).

Protocol
  • Sample (dry tube and EDTA + aprotinin tube) on d0 at 8 a.m.
  • At midnight, 1 mg dexamethasone orally.
  • Sample (dry tube and EDTA + aprotinin tube) the next day at 8 a.m.
Samples
  • For the cortisol assay: store serum samples at +4°C.
  • For ACTH: Freeze EDTA plasma at –20°C.
Assays

Cortisol and/or ACTH.

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