List of dynamic tests
Purpose
To detect gastrin hypersecretion in Zollinger-Ellison syndrome.
Produit
- Sekretolin Diagnosticum® (vials)
- Normal saline (250 ml).
Dose
3 CU/kg body weight.
Subject preparation
- Fasting for 12 hours.
- Discontinue secretion inhibitors for 48 hours.
Protocol
- Sample (dry tube) at time interval 0.
- Slow (one hour) infusion of the correct dose of secretin in 250 ml normal saline.
- Samples (dry tubes) taken 15, 30 and 45 minutes after the beginning of infusion, at the end of infusion (T+60) and 15 minutes later (T+75).
Samples
After centrifugation, draw off the serum and freeze as soon as possible at –20°C.
Assay
Gastrin.
Side effects
Rare: nausea, mild headache.
