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Secretin test

List of dynamic tests
Purpose

To detect gastrin hypersecretion in Zollinger-Ellison syndrome.

Produit
  • Sekretolin Diagnosticum® (vials)
  • Normal saline (250 ml).
Dose

3 CU/kg body weight.

Subject preparation
  • Fasting for 12 hours.
  • Discontinue secretion inhibitors for 48 hours.
Protocol
  • Sample (dry tube) at time interval 0.
  • Slow (one hour) infusion of the correct dose of secretin in 250 ml normal saline.
  • Samples (dry tubes) taken 15, 30 and 45 minutes after the beginning of infusion, at the end of infusion (T+60) and 15 minutes later (T+75).
Samples

After centrifugation, draw off the serum and freeze as soon as possible at –20°C.

Assay

Gastrin.

Side effects

Rare: nausea, mild headache.

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