Eurofins Biomnis code

17PRE

Synonyms

• Delta-5-pregnenolone
• Pregnenolone - 17-Hydroxy
• Pregnenolone - 17-OH-
• 17-Hydroxy-delta-5-pregnenolone
• 17-OH-pregnenolone

Specialty

Biochemistry

Clinical significance

Derived from pregnenolone by the action of 17-alpha hydroxylase and subsequently converted into 17 alpha hydroxypregesterone or DHEA (both the delta-4 and delta-5 pathways exist). Useful in the evaluation of hyperandrogenism due to 3-beta-hydroxy-dehydrogenase deficiency. Complete deficiency is manifested within the first few days of life but partial deficiency is often not discovered until hyperandrogenism or infertility is diagnosed in an adult.

Preanalytics

• 2 mL :
• serum
•   Reftrigerated

• A tube specifically for this analysis : No

Further information

CIRCADIAN RHYTHM: This biological molecule has a circadian rhythm (maximum concentration in morning), with a sufficiently significant amplitude to have an important influence on the clinical interpretation

Methodology

Chromatography - Extraction - Radioimmunoassay

Turnaround time

2 weeks