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HomeServicesTest guide21-Deoxycortisol - serum
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21-Deoxycortisol - serum

Other tests

Biomnis code

21DF

Synonyms

  • 21-DF
  • Cortisol - 21-Deoxy
  • 21-Deoxy F
  • 21-DOB

Clinic significance

Synthesized by the adrenal cortex from 17-OHP by the action of 11-beta-hydroxylase. The metabolic pathway is a minor one in normal subjects but assumes importance in those with congenital hyperplasia of the adrenal gland due to 21-hydroxylase deficiency. Complete deficiency is identified at birth in 80% of cases and excess androgens during childhood lead to over-rapid bone development and precocious pseudopuberty. Incomplete deficiency is more common (0,5 to 20% of the population) and is associated with hirsutism, acne vulgaris and alopecia. 11-deoxycortisol levels rise dramatically in a short Synacthen (adrenocortical stimulation) test.

Preanalytical

  • 3 mL
  • Serum
  • Refrigerated

Further information

  • CIRCADIAN RHYTHM: This biological molecule has a circadian rhythm (maximum concentration in morning), with a sufficiently significant amplitude to have an important influence on the clinical interpretation

Methodology

Chromatography - Extraction - Radioimmunoassay

Turn around Time

2 weeks (if dilution/control needed - TAT 4 weeks)


Pathologist(s) in charge
Biomnis Paris
Specialty
Biochemistry
Contact(s)
Dr Jean Marc VANDERNOTTE
Dr Laurence STROMPF - SILVESTRE
Phone(s)
+331 49 59 63 01
+331 49 59 63 14

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