Eurofins Biomnis code

21T

Synonyms

• Down syndrome
• HT21
• Serum markers for Trisomy 21
• Serum screening for Trisomy 21 risk
• Trisomy 21 - double test
• T21 - serum markers
• T21 MSM

Specialty

Down Syndrome screening and foetal biochemistry

Clinical significance

A set of tests for pregnant women based on two or three markers (free beta hCG, AFP and, on request unconjugated estriol) carried out between 15 and 20 completed weeks of gestation. Software, specially designed for the reagents used, calculates the risk of Down syndrome and non-closure of the neural tube from the test results together with relevant data provided by the subject's physician (the mother's date of birth and weight, and the term of the pregnancy - preferably estimated on the basis of ultrasound data). When the risk of Down's syndrome is superior or equal at 1/50, the foetal karyotype is covered by French social security . When the risk is between 1/51 and 1/1000, screening by circulating free fetal DNA (NIPT) is covered by the CPAM. (applicalble for French lab only).

Preanalytics

• 3 mL :
• Serum (do not use plasma)
•   Refrigerated

• A tube specifically for this analysis : No

Further information

If a sample is taken from a gel tube, it is necessary to send a decanted serum
Non hemolysed, non-icteric, non lipemic sample. Sample must be centrifuged as quickly as possible and international samples must be frozen within 4 hours of sampling.
Please conserve an additional sample in your serolibrary until you have received the result.
In accordance with French regulation, ALWAYS attach the prescription, a copy of the ultrasound report and a copy of the patient consent form, signed by both the patient and the physician.

Documents to download

• Specific Request form B2(INTGB)

Methodology

Fluoro-Immunoassay (time resolved)

Turnaround time

3 days