Eurofins Biomnis code

ACC

Synonyms

• ACC
• Anti-prothrombinase antibodies
• Circulating lupus anticoagulant
• Dilute Russell's viper venom time
• dRVVT
• LA
• Lupus anticoagulant
• Rosner index

Specialty

Haematology

Clinical significance

Circulating lupus anticoagulants (also called lupus antibodies) are defined by their in vitro inhibitory activity on phospholipid-dependent coagulation reactions. The presence of anti-phospholipid antibodies (LA or anti-cardiolipin antibodies) is associated with recurrent venous or arterial thrombosis and/or recurrent abortions. This condition may be primary or secondary to a range of etiologies including autoimmune disease (e.g. SLE), neoplasia and certain types of infection. LA are often detected in children who have recently undergone tonsilectomy or adenoidectomy but this is usually an insignificant result not indicating any predisposition to thrombosis or hemorrhage; in most such cases, the LA disappear within six months.

Preanalytics

• 2 mL :
• Citrated Plasma
•   FROZEN
• 4h

• A tube specifically for this analysis : No

Further information

Enclose the specific clinical information form (R5-INTGB : Haemostasis)
Plasma with platelets removed by double centrifugation: 2500 g 15 min and settled plasma. The patient must not receive heparin.
The sample must be drawn at distance from any heparin treatment (UFH, LMWH, danaproid sodium)(2 days of turnaround time), rivaroxaban (XARELTO), apixaban (ELIQUIS), dabigatran (PRADAXA) (4 to 5 days of turnaround time).
It is advisable to send us a frozen and centrifuged citrate sample in compliance with the GFHT pre-analytical recommendations.
The assay should be performed after a 5-day discontinuation of the ODA treatment

Documents to download

• Specific clinical information form (R5-INTGB)

Methodology

Chronometric method

Turnaround time

1 day