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HomeServicesTest guideCirculating Lupus anticoagulant - screening - plasma
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Circulating Lupus anticoagulant - screening - plasma

Other tests

Eurofins Biomnis code

ACC

Synonyms

  • LA
  • Rosner index
  • Lupus anticoagulant
  • Dilute Russell's viper venom time
  • dRVVT
  • Circulating lupus anticoagulant
  • ACC
  • Anti-prothrombinase antibodies

Clinic significance

Circulating lupus anticoagulants (also called lupus antibodies) are defined by their in vitro inhibitory activity on phospholipid-dependent coagulation reactions. The presence of anti-phospholipid antibodies (LA or anti-cardiolipin antibodies) is associated with recurrent venous or arterial thrombosis and/or recurrent abortions. This condition may be primary or secondary to a range of etiologies including autoimmune disease (e.g. SLE), neoplasia and certain types of infection. LA are often detected in children who have recently undergone tonsilectomy or adenoidectomy but this is usually an insignificant result not indicating any predisposition to thrombosis or hemorrhage; in most such cases, the LA disappear within six months.

Pre-analytical

  • 2 mL
  • Citrated Plasma
  • FROZEN

Further information

  • Plasma with platelets removed by double centrifugation: 2500 g 15 min and settled plasma. The patient must not receive heparin.
  • It is advisable to send us a frozen and centrifuged citrate sample in compliance with the GFHT pre-analytical recommendations.
  • Enclose the specific clinical information form (R5-INTGB : Haemostasis)
  • The sample must be drawn at distance from any heparin treatment (UFH, LMWH, danaproid sodium)(2 days of turnaround time), rivaroxaban (XARELTO), apixaban (ELIQUIS), dabigatran (PRADAXA) (4 to 5 days of turnaround time).

Methodology

Chronometric method

Turn around Time

2 days


Pathologist(s) in charge
Biomnis Paris
Specialty
Haematology
Contact(s)
Dr Léna LE FLEM
Dr Dominique ENGERAND
Phone(s)
+331 49 59 17 44
+331 49 59 62 70

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