Eurofins Biomnis code

ACFIN

Synonyms

• Anti-FI antibodies
• Intrinsic factor - anti-antibodies
• Castle's intrinsic factor
• FIN - anti-antibodies

Clinic significance

Detectable in 65% of patients with pernicious anemia (megaloblastic anemia due to poor vitamin B12 absorption and associated with chronic gastritis). The antibodies which bind intrinsic factor are of two distinct types:- Type I are blocking antibodies which bind to the molecule's vitamin B12-binding site;- Type II are non-blocking and can bind to intrinsic factor whether or not it is complexed with vitamin B12.

Prenalytics

• 1 mL
• Serum
• Refrigerated

Methodology

Enzyme-immunoassay

Turnaround time

2 days