Eurofins Biomnis code

ALDO

Synonyms

• Endocrinology
• Mineralocorticoid

Specialty

Biochemistry

Clinical significance

The major mineralocorticoid hormone synthesized in the zona glomerulosa of the adrenal cortex. The rate of its secretion depends on three factors: the blood potassium concentration, corticotropin and the renin-angiotensin system. Aldosterone levels are high in primary aldosteronism (which is characterized by high blood pressure, polydipsia, polyuria with very dilute urine, asthenia and sometimes episodes of tetanus). Hypoaldosteronism is rare and may be secondary to some primary insufficiency (e.g. Addison's disease). Aldosterone levels are affected by a wide range of drugs including spironolactone, diuretics, angiotensin-converting enzyme inhibitors, laxatives, beta-adrenoreceptor-blockers and stimulants, and oral contraceptives. Anti-hypertensive drugs and calcium inhibitors have no effect on aldosterone levels.

Preanalytics

• 1 mL :
• Plasma EDTA
•   FROZEN
• Freezing within 4 hours

• A tube specifically for this analysis : No

Further information

Optimal sampling conditions according to SFE / SFHTA / AFCE: in the morning, more than 2 hours after waking up, in a sitting position after 5 to 15 minutes, with normal dietary salt intake, normal kalemia, and without antihypertensive drugs that significantly interfere with the renin-angiotensin-aldosterone system. Antihypertensive medications that can be maintained during exploration include alpha-blockers and calcium channel blockers.
Do not refer haemolysed or lipemic samples.
DIET INFORMATION: our reference ranges are only valid for a normal salt intake (80-250mEq/24hrs natriuresis )
Specify standing or inclined:
Sampling in vertical position after 1 hour of walking: ALDOD
Sampling in the reclined position, after 1 h in the supine position: ALDOC

Methodology

Radioimmunoassay

Turnaround time

2 days