anisakiasis - Specific IgE and IgG4 - serum

Eurofins Biomnis code

ANIS

Synonyms

• anisakis
• Anisakis

Clinic significance

Anisakiasis is a parasitic infection caused by ingestion of larvae of nematodes of the Anisakidae family. The larvae are present in infected fish, and transmission occurs when the fish is consumed raw or undercooked.
In the acute phase, human infestation results in gastrointestinal symptoms in the form of gastric pain; a late intestinal form may also be observed. These forms may be accompanied by allergic reactions (anaphylactic shock, angioedema, urticaria, asthma).
Chronic forms, specifically GAA and CU+*, may also be observed as a result of the long-term consumption of infected cooked fish.
*GAA: gastro-allergic anisakiasis; CU+: Anisakis simplex sensitization-associated chronic urticaria
Measurement of specific IgE for p4 and specific IgG4 for p4 must be interpreted based on clinical data (acute and chronic anisakiasis), presence of eosinophilia, time between onset of clinical symptoms and sample collection, and finally based on cross-reactivity between nematodes, cockroaches, mites, crustaceans, etc.

Prenalytics

• 1 mL
• Serum
• Refrigerated

Further information

Methodology

Fluorescent enzyme-immunoassay

Turnaround time

1 week