Eurofins Biomnis code

CAL

Synonyms

• Stone analysis
• Urinary calculi
• urinary lithiasis

Specialty

Analytical Chemistry

Clinical significance

Lithiasis is a common problem which affects between 4 and 20% of the population (according to different studies). It recurs at least once in 60% of cases and many times in 5 to 6% of patients, putting them at risk of renal insufficiency. Examination of the morphology and composition of a calculus helps identify the biochemical factors underlying the lithiasis and thus aids with both defining the etiology of the problem (e.g. metabolic disease, nutritional factors, etc.) and deciding on appropriate preventive treatment. The examination consists of two different steps : - binocular microscope examination of the surface and, after sectioning, successive internal layers of the calculus - to include inspection of the nucleus, if there is one; - infrared spectrophotometry to analyze the composition of the calculus, - identification of all organic or mineral material, both amorphous and crystalline, - analysis of the different crystalline substances present, - semi-quantitative estimation of the amounts of the various different substances present, - localization of all the substances contained in the calculus (analysis of successive layers going from the nucleus out to the surface), - screening for drug-induced and false calculi.

Preanalytics

• stone(s) or filtered urinary deposit
•   Ambient temperature

• A tube specifically for this analysis : No

Further information

Enclose the specific clinical information form (R32-INTGB urinary tract lithiasis)
Send the entire calculus, previously washed and dried in a sterile container which does not contain any compound (no borate in particular). Urines is not accepted.

Documents to download

• Clinical information form (R32-INTGB)

Methodology

Morphological analysis and infrared spectrophotometry (SPIR)

Turnaround time

14 days