Eurofins Biomnis code

CD48

Synonyms

• CD3+
• CD3 lymphocytes
• CD3/CD4/CD8
• Cytometry
• Lymphocyte immunophenotyping
• Lymphocyte typing
• Phenotyping
• T lymphocytes
• T3, T4, T8

Specialty

Haematology

Clinical significance

The CD4+ lymphocyte (or "helper" cells, a T lymphocyte sub-population) represents one of the cell-types that the Human Immunodeficiency Virus (HIV) can infect. The number of circulating CD4+ T lymphocytes is one of the most useful parameters for following the progress of HIV disease. These counts should be performed every 6 months as long as there are over 500 million CD4+ cells per liter of blood. At this stage of infection, viral load is low and the patient is usually completely asymptomatic. If the number of cells is between 200 and 500 million per liter, the test should be performed every 3 months - antiviral treatment is usually commenced in patients with a CD4 count of about 350 million together with symptoms of progressive disease and an increasing viral load (over 3,000 copies per milliliter).The CD8+ sub-population of T lymphocytes (T for "Thymo-dependent") is defined as mediating cytotoxic-suppressor activity. An increase in the number of CD8+ cells is observed in HIV infection, sometimes at an early stage, and these cells are believed to play an important role in defense against this virus.

Preanalytics

• 3 mL :
• EDTA whole blood
•   Ambient temperature

• A tube specifically for this analysis : No

Further information

The sample must reach us WITHOUT FAIL within 24 hrs of sampling.
Analytical stability : 96h
Always attach the lymphocyte count performed on the same day as sampling or fax to 01 49 59 17 98

Methodology

Flow Cytometry

Turnaround time

1 day