Clozapine

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Eurofins Biomnis code

CLOZA

Synonyms
  • Desmethylclozapine
  • Leponex®
  • Norclozapine
Specialty

Analytical Chemistry


Clinical significance

A major neuroleptic of the dibenzodiazepine class with strong anti-psychotic activity. Half-life = 12 hours. Test useful for monitoring treatment, establishing the correct dose and detecting evidence of toxicity (especially heart toxicity).

Preanalytics
  • 1 mL :
  • lithium heparin plasma (do not use tubes with separator gel)
  •   Reftrigerated
  • A tube specifically for this analysis : Yes
Further information

Enclose the specific clinical information form (R13-INTGB : Medication quantification)
1 individual aliquot for this analysis.
Always draw blood at the same time before another administration
The following examinations can be performed on the same sample: Aripiprazole; Clozapine; Haloperidol; olanzapine; Quétiapine; Rispéridone.


Methodology

Liquid chromatography / Tandem mass spectrometry (LC-TMS/MS)

Turnaround time

1 week


Testing Laboratory

Biomnis Lyon