11-Desoxycortisol - Compound S - - Serum
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COMPS
Synonyms
- Compound S
- Cortexolone
- deoxycortisol - 11
- Endocrinology
- 11-DF
Specialty
Biochemistry
Clinical significance
An adrenal steroid intermediate in cortisol biosynthesis. Derived from the conversion of 17-hydroxyprogesterone by 21-hydroxylase. It is one of the 17-hydroxycorticosteroids and is useful in the diagnosis of 11-beta-hydroxylase deficiency in congenital adrenal hyperplasia and for the evaluation of anterior pituitary insufficiency (Metyrapone test). Metyrapone specifically blocks the conversion of 11-deoxycortisol to cortisol; as a consequence, the plasma cortisol concentration falls so the normal anterior pituitary secretes more corticotropin and 11-deoxycortisol levels begin to increase again.
Preanalytics
- 500 µL :
- Serum (do not use tubes with separator gel)
- Reftrigerated
- A tube specifically for this analysis : No
Further information
CIRCADIAN RHYTHM: This biological molecule has a circadian rhythm (maximum concentration in morning), with a sufficiently significant amplitude to have an important influence on the clinical interpretation
Methodology
LC-MS/MS
Turnaround time
1 week
Biomnis Lyon