11-Desoxycortisol - Compound S - - Serum

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Eurofins Biomnis code

COMPS

Synonyms
  • Compound S
  • Cortexolone
  • deoxycortisol - 11
  • Endocrinology
  • 11-DF
Specialty

Biochemistry

Clinical significance

An adrenal steroid intermediate in cortisol biosynthesis. Derived from the conversion of 17-hydroxyprogesterone by 21-hydroxylase. It is one of the 17-hydroxycorticosteroids and is useful in the diagnosis of 11-beta-hydroxylase deficiency in congenital adrenal hyperplasia and for the evaluation of anterior pituitary insufficiency (Metyrapone test). Metyrapone specifically blocks the conversion of 11-deoxycortisol to cortisol; as a consequence, the plasma cortisol concentration falls so the normal anterior pituitary secretes more corticotropin and 11-deoxycortisol levels begin to increase again.

Preanalytics
  • A tube specifically for this analysis : No
Further information

CIRCADIAN RHYTHM: This biological molecule has a circadian rhythm (maximum concentration in morning), with a sufficiently significant amplitude to have an important influence on the clinical interpretation

Methodology

LC-MS/MS

Turnaround time

1 week

Testing Laboratory

Biomnis Lyon

Contact(s)
Customer Care