Eurofins Biomnis code

COMPS

Synonyms

• Cortexolone
• Compound S
• deoxycortisol - 11
• Endocrinology
• 11-DF

Clinic significance

An adrenal steroid intermediate in cortisol biosynthesis. Derived from the conversion of 17-hydroxyprogesterone by 21-hydroxylase. It is one of the 17-hydroxycorticosteroids and is useful in the diagnosis of 11-beta-hydroxylase deficiency in congenital adrenal hyperplasia and for the evaluation of anterior pituitary insufficiency (Metyrapone test). Metyrapone specifically blocks the conversion of 11-deoxycortisol to cortisol; as a consequence, the plasma cortisol concentration falls so the normal anterior pituitary secretes more corticotropin and 11-deoxycortisol levels begin to increase again.

Prenalytics

• 2 mL
• Serum
• Refrigerated

Further information

• CIRCADIAN RHYTHM: This biological molecule has a circadian rhythm (maximum concentration in morning), with a sufficiently significant amplitude to have an important influence on the clinical interpretation

Methodology

Chromatography - Extraction - Radioimmunoassay

Turnaround time

1 week