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HomeServicesTest guide11-Deoxycorticol - Compound S - serum
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11-Deoxycorticol - Compound S - serum

Other tests

Biomnis code

COMPS

Synonyms

  • deoxycortisol - 11
  • Cortexolone
  • Compound S
  • 11-DF

Clinic significance

An adrenal steroid intermediate in cortisol biosynthesis. Derived from the conversion of 17-hydroxyprogesterone by 21-hydroxylase. It is one of the 17-hydroxycorticosteroids and is useful in the diagnosis of 11-beta-hydroxylase deficiency in congenital adrenal hyperplasia and for the evaluation of anterior pituitary insufficiency (Metyrapone test). Metyrapone specifically blocks the conversion of 11-deoxycortisol to cortisol; as a consequence, the plasma cortisol concentration falls so the normal anterior pituitary secretes more corticotropin and 11-deoxycortisol levels begin to increase again.

Preanalytical

  • 2 mL
  • Serum
  • Refrigerated

Further information

  • CIRCADIAN RHYTHM: This biological molecule has a circadian rhythm (maximum concentration in morning), with a sufficiently significant amplitude to have an important influence on the clinical interpretation

Methodology

Chromatography - Extraction - Radioimmunoassay

Turn around Time

1 week


Pathologist(s) in charge
Biomnis Paris
Specialty
Biochemistry
Contact(s)
Dr Jean Marc VANDERNOTTE
Dr Laurence STROMPF - SILVESTRE
Phone(s)
+331 49 59 63 01
+331 49 59 63 14

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