Eurofins Biomnis code

COR

Synonyms

• Compound F
• Endocrinology
• Glucocorticoid
• Hydrocortisone

Specialty

Biochemistry

Clinical significance

The major natural glucocorticoid hormone synthesized from cholesterol in the zona fasciculata and the zona reticularis of the adrenal cortex. Its secretion is regulated by ACTH and, in a negative feedback loop, by Corticotropin Releasing Factor (CRF) produced in the hypothalamus. Cortisol has glucocorticoid activity (it affects glucose, lipid and protein metabolism). High levels are observed in Cushing's-type syndromes, e.g. Cushing's disease and secondary to adrenal neoplasm. Low levels occur in adrenal insufficiency, e.g. Addison's disease, congenital adrenal hyperplasia due to certain enzyme deficiencies, anterior pituitary insufficiency and in patients on long term corticosteroid therapy. Changes in cortisol levels are monitored in a number of dynamic tests including Synacthen stimulation. and Dexamethasone suppression

Preanalytics

• 1 mL :
• serum
•   Reftrigerated

• A tube specifically for this analysis : No

Further information

Collect the sample in the morning between 7 and 10 am, or according to the instructions from the prescribing party
CIRCADIAN RHYTHM: This biological molecule has a circadian rhythm (maximum concentration in morning), with a sufficiently significant amplitude to have an important influence on the clinical interpretation
ATTENTION: interference possible in patients treated with biotin (vitamin B7, B8 or H) or taking any food supplement containing biotin. Essential to STOP treatment 8 days before taking the sample.

Methodology

chimiluminescence (CMIA)

Turnaround time

1 day