Eurofins Biomnis code

COXBM

Synonyms

• Coxsackie virus groupes A et B
• Echovirus
• Enterovirus
• Entérovirus

Specialty

Infectious

Clinical significance

The Enterovirus genus, in the Picornaviridae family, is composed of small non-enveloped RNA viruses. It currently includes more than a hundred serotypes that are pathogenic for humans, divided into five species (poliovirus and human enterovirus A-D - old classification). These viruses are highly resistant in the external environment and are transmitted mainly via the faecal-oral route, but also via the air, conjunctival or transplacental routes. Non-polio enteroviruses are considered to be one of the main causes of viral infection in children and adults. Non-polio enteroviruses include group A and B coxsackie viruses and echoviruses.Although most enterovirus infections are asymptomatic or even paucisymptomatic, these ubiquitous pathogens are responsible for a variety of infectious syndromes. - upper respiratory tract infections (rhinitis, pharyngitis, otitis) or lower respiratory tract infections (pneumonia, bronchiolitis); - damage to the cardiovascular system (myopericarditis, vasculitis, dilated cardiomyopathy); - damage to the nervous system: seasonal lymphocytic meningitis (spring/summer), more rarely encephalitis, or pseudo-poliomyelitic paralytic syndrome; - conjunctivitis - muscular damage: Bornholm disease with myalgic syndrome; - skin damage with rashes and mucous membranes (herpangina and hand-foot-and-mouth syndrome).Newborns may suffer from severe multisystem symptoms.Hand-foot-and-mouth disease and herpangina are more often associated with group A coxsackie viruses, while echoviruses are often responsible for viral meningitis.Excretion occurs via the digestive tract, regardless of the symptoms observed.Testing for the enterovirus genome by real-time RT-PCR in CSF and other peripheral samples (stools, throat swabs, respiratory samples) enables rapid, reliable diagnosis, particularly of meningeal disease.

Preanalytics

•  :
• 1 ml CSF, nasopharynx/throat, respiratory swabs, mucocutaneous swab, eye swab, stool, serum, plasma.
•   Refrigerated

• A tube specifically for this analysis : No

Further information

[To be translated]
The use of the S14UK transport bag is Mandatory.
Swab samples require the use of a transport medium (viral) supplied in kit K1.
Samples (other than swabs) must be sent as they are, in sterile bottles, without transport medium.

Specific equipment available

• S14: Special mycobacteria transport bags are to be used

Documents to download

• information note (N23-INTGB)

Methodology

Real-time PCR

Turnaround time

1 day