Eurofins Biomnis code

CPEP

Synonyms

• C-peptide
• Endocrinology

Specialty

Biochemistry

Clinical significance

C-Peptide is a polypeptide chain of molecular mass approximating 3020 daltons. It is derived from the breakdown of PROINSULIN by proteolytic cleavage into Insulin and C -Peptide. Both insulin and C-Peptide are released into portal circulation in equimolar amounts. Pancreatic cell function is assessed by its ability to secrete insulin. This is applicable in healthy individuals and insulin independent diabetics. In subjects on long term insulin therapy the measurement of serum insulin will yield false results due to the formation of insulin antibodies in the patient's serum. In insulin treated subjects C-Peptide measurements offer an indirect monitor of insulin secretion in the presence of anti-insulin antibodies and determines the appropriate course of treatment. C-Peptide measurements are also of value in insulinomas and following post pancreatectomy.The measurement can also be undertaken in urine samples which is of value in representing the integrated levels over a 24 hour collection period. Test useful in: - evaluating residual beta cell activity in diabetics on insulin therapy; - differential diagnosis of insulin-dependent and non-insulin-dependent diabetes; - diagnosis of insulinoma; - post-pancreatectomy monitoring.

Preanalytics

• 1 x 1 mL :
• serum
•   FROZEN
• Freezing within 4 hours

• A tube specifically for this analysis : No

Further information

Fasting sample

Methodology

EIA

Turnaround time

1 day