Eurofins Biomnis code

CRYOI

Synonyms

• [To be translated]

Specialty

Haematology

Clinical significance

Globulins which precipitate at lower temperatures but which re-dissolve at 37°C. Three types are recognized: monoclonal immunoglobulins (usually IgM-IgG), mixed monoclonal and polyclonal immunoglobulins (usually monoclonal IgM-polyclonal IgG) and mixed polyclonal immunoglobulins (usually IgM-IgG.This cryoprecipitation phenomenon is due to a lack of sialic acid residues as the immunoglobulin molecules have undergone heavy desialylation. Various underlying reasons can cause cryoglobulinemia, including hyperactivation of the immune system, overactive desialylation machinery and liver disease (hepatitis and cirrhosis).NB: the link between cryoglobulinemia and hepatitis C should be emphasized. N.B: Of course, this analysis is only carried out if the cryoglobulin test (CROYR code analysis) is positive.

Preanalytics

• 4 mL :
• Serum (no tube with separator)
•   Reftrigerated

• A tube specifically for this analysis : Yes

Further information

Fasting sample
1 individual aliquot for this analysis.
Sampling in kit at +37°C. Coagulation and settling for 2 hours at +37°C, and decanting after centrifugation (15 mins at 2100g at +37°C).A sufficient volume of serum is essential to obtain a clear cryoprecipitate

Methodology

Immunofixation

Turnaround time

2 days