Eurofins Biomnis code

CYS

Specialty

Biochemistry

Clinical significance

Cystatin C, also known as gamma trace or post gamma globulin, is the principal inhibitor of cystenin proteases. Constructed with a single non glycosylated polypeptide chain of 120 amino acids, this protein is produced by nucleated cells, particularly at times of inflammation, infection and cancer etc. Its weak molecular structure and its positive charge allows it to pass via the glomerular filter with ease, where it is reabsorbs and catabolised by proximal tubular cells. The serum concentration of cystatin C is a good reflection of glomerular filtration rates. After renal transplantation the cystatin C levels can be studied to indicate the acceptance of a graft. In oncology, the cystatin C levels can determine glomerular function for early detection.

Preanalytics

• 1 mL :
• serum
•   Reftrigerated

• A tube specifically for this analysis : No

Methodology

Nephelometry

Turnaround time

2 days