Dengue fever - direct diagnosis - PCR
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DENBM
Synonyms
- Arbovirus
Specialty
Infectious
Clinical significance
It is an RNA virus belonging to the Flaviviridae family, with four different serotypes. The dengue virus is transmitted by a mosquito (Aedes). The infection is widespread in Central and South America, the Indian Ocean, Africa and South-East Asia. In 2022, the transmission of the dengue virus in mainland France was exceptional, with around sixty indigenous cases identified. In its common form, dengue fever is associated with a febrile flu-like syndrome, with a sudden onset, accompanied by muscle and joint pains and a skin rash that resolves spontaneously in around 1 week. Severe forms may occur, with neurological or haemorrhagic damage. During the viremia period, detection of the viral genome by PCR is the reference method for direct diagnosis. Testing for the NS1 antigen in serum, using an ELISA-type test or a rapid immunochromatographic test, can be carried out up to the 7th day after the onset of symptoms. From the 5th to 7th day after the onset of symptoms, specific IgM appear and serology is the diagnostic method of choice. Dengue fever is a reportable disease.
Further information
Enclose the specific clinical information form (R28-INTGB : Dengue-Chikungunya-West Nile-Zika)
The use of the S14UK transport bag is Mandatory.
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Documents to download
Methodology
Real-time PCR
Turnaround time
3 days
Biomnis Lyon
