Eurofins Biomnis code

DIGO

Synonyms

• Hemigoxine®

Specialty

Analytical Chemistry

Clinical significance

A cardiac glycoside used to treat congestive heart failure and certain kinds of arrhythmia.70% is reabsorbed in the intestine. 20% is bound to plasma proteins. Little metabolism in the liver. Rapidly eliminated, mainly (90%) in the urine with complete clearance in 2 to 6 days. Dose should be adjusted for patients with impaired renal function.Stable concentration reached in 5 to 8 dayswith a half-life = 1.5 days.Overdosage results in gastrointestinal symptoms (anorexia, nausea and vomiting) and neurosensory problems (dizziness, headaches and yellow-hued vision) with the most serious toxicity in the heart with impaired conduction and enhanced excitability. Low blood potassium or high blood calcium can potentiate its activity.

Preanalytics

• 1 mL :
• Sérum
•   FROZEN
• Freezing within 4 hours

• A tube specifically for this analysis : Yes

Further information

Enclose the specific clinical information form (R13-INTGB : Medication quantification)
1 specific aliquot for this analysis
Always draw blood at the same time before another administration

Documents to download

• Specific clinical information form (R13-INTGB)

Methodology

Kinetic interaction of microparticules in solution (KIMS)

Turnaround time

1 day