Eurofins Biomnis code

EBVBM

Synonyms

• EBV

Specialty

Infectious

Clinical significance

Epstein Barr virus (EBV) belongs to the Herpesviridae family. Primary infection is very frequent and often asymptomatic in children. EBV can cause Infectious Mononucleosis (IM) in adolescents and young adults. Diagnosis is based on serology and, in very rare cases where serology is uninterpretable, on detection of the viral genome in the blood. IMD can sometimes cause hepatic, neurological, haematological, cardiac and pulmonary complications. In immunocompetent patients, asymptomatic reactivations are frequent and are associated with salivary excretion of the virus.EBV also causes lymphoproliferative syndromes in immunocompetent patients (lymphoma, nasopharyngeal carcinoma) and in immunocompromised patients (post-transplant lymphoproliferative syndrome, lymphoma). These manifestations are the result of the presence of the virus in latent form in B lymphocytes. Certain viral proteins cause them to proliferate. Measuring the EBV viral load in the blood helps in the diagnosis and monitoring of these diseases.

Preanalytics

•  :
• Bronchial aspirations, BAL, ocular humor, biopsies (including digestive, pulmonary, cerebral), puncture fluid (pleural or pericardial), bone marrow (EDTA), CSF: qualitative result
•   Reftrigerated

• A tube specifically for this analysis : No

Further information

.
[To be translated]
The use of the S14UK transport bag is Mandatory.
Swab samples require the use of a transport medium (viral) supplied in kit K1.
Samples (other than swabs) must be sent as they are, in sterile bottles, without transport medium.

Specific equipment available

• S14: Special mycobacteria transport bags are to be used

Methodology

Real-time PCR

Turnaround time

3 days