Eurofins Biomnis code

EBVG

Synonyms

• EBNA - IgG serology
• EBV
• IMN
• Infectious mononucleosis
• VCA - IgG serology

Specialty

Infectious

Clinical significance

Epstein Barr Virus (EBV) of the herpesviridae family with an affinity for B lymphocytes. EBV Infects a large voulme of the population, with transmission by saliva. The primary infection occurs during infancy, where it is often non specific and asymptomatic, then presents itself in an infectious stage in adolescence. The organism persists in the body in the latent stage, and can be silently reactivated. EBV is an oncogene virus, especially with the immunosuppressed, and can cause severe effects including, meningocephalitis, polyradculoneuritis, hepatitis,oral and scalp leukoplakia.EBV is associated with men following a neoplastic process; carcinoma of the naso pharynx (NPC), Burkitt Lymphoma, the immunosuppressed, (transplant, AIDS) and B cell immunoblastic lymphoma . Isolation of the virus is practically difficult to perform. The molecular study by PCR in blood, CSF or hepatic biopsy is indicative of viral development. The classic associated serology is the presence of IgG, IgM anti VCA and IgG anti EBNA. The IgM is present in the first three months, with Anti EBNA presented at the end of these three months. IgG Anti EA is present in active infections. IgA anti VCA antibodies and anti EA Antibodies are raised in the case of NPC. EBV can be implicated in the case of mengioencephalitis (subjet to immuno depression) and certain cases of myelinitis.

Preanalytics

• 1 mL :
• serum
•   Reftrigerated

• A tube specifically for this analysis : No

Further information

Storage temperature (2-8°C) < 7 days during transport of specimen.

Methodology

EIA

Turnaround time

2 days