Eurofins Biomnis code

EPHB

Synonyms

• Haemoglobin anomaly
• Haemoglobin electrophoresis
• Sickle cell disease
• Test d'Itano
• Thalassemia

Specialty

Haematology

Clinical significance

The various forms of hemoglobinopathy are characterized by genetically determined, quantitative or qualitative abnormalities in hemoglobin. In most cases, diagnosis depends on studying the expressed hemoglobin by automated High Performance Liquid Chromatography (HPLC) or isoelectric focusing. Quantitative abnormalities involve reduced synthesis of normal globin sub-units: reduced synthesis of the alpha sub-unit causes alpha-thalassemia and reduced synthesis of the beta sub-unit causes beta-thalassemia. The most common forms of qualitatively abnormal hemoglobin are HbS, HbC, HbE, HbLepore. HbS is the form of hemoglobin which is associated with sickle cell anemia.

Preanalytics

• 4 mL :
• whole blood
•   Reftrigerated

• A tube specifically for this analysis : Yes

Further information

Attach the FBC results
Specify ethnic origin
The sample has to be collected just before to be sent to our facility in order to minimize the transport time and the impact on the sample stability.
The sample is stable for 7 days from its extraction
In the event of an Hb abnormality identified with capillary electrophoresis, an EPHBI is triggered supplemented by a HPLC technique and acid gel electrophoresis.

Methodology

Electrophoresis

Turnaround time

2 days