Eurofins Biomnis code

FAC10

Synonyms

• Stuart - factor
• Stuart factor

Specialty

Haematology

Clinical significance

Congenital Factor X deficiency is an autosomal recessive trait. Severe deficiency (i.e. the homozygous state or complementary mutations in the same gene) is rare. Heterozygotes only hemorrhage following serious trauma, e.g. surgery. Replacement therapy (by PPSB-SD) should aim at keeping Factor X levels above 25% of the normal level.Acquired Factor X deficiency is sometimes secondary to vitamin K deficiency in which case there is concomitant deficiency in Factors II, VII and IX; this can be induced by vitamin K antagonist drugs or by inadequate intake or absorption of this vitamin. Acquired Factor V deficiency may also be associated with liver disease, fibrinolysis and diffuse intravascular coagulation. In this case, deficiencies will also be observed in Factors II, V and VII. Isolated Factor X deficiency has been reported in amyloidosis.

Preanalytics

• 2 mL :
• Citrated Plasma
•   FROZEN
• Freezing within 4 hours

• A tube specifically for this analysis : No

Further information

Enclose the specific clinical information form (R5-INTGB : Haemostasis)
Single tube possible for II, V, VII, X
The factors II, V, VII, X (prothrombin complex factors) assay requires at least 2 mL of citrate plasma frozen
Attach patient¿s clinical details (inflammatory syndrome, pregnancy, family history) and the context of the test prescription request (haemorrhages, thrombosis, preoperative care, replacement therapy...) and any possible therapeutic prescription information.
It is advisable to send us a frozen and centrifuged citrate sample in compliance with the GFHT pre-analytical recommendations.

Documents to download

• Specific clinical information form (R5-INTGB)

Methodology

Chronometric method

Turnaround time

1 day