Eurofins Biomnis code

FAC13

Synonyms

• Factor 13
• Fibrin stabilising factor
• FSF

Specialty

Haematology

Clinical significance

Factor XIII deficiency is an autosomal recessive trait and the homozygous state is very rare. Severe deficiency is seen in both homozygotes and subjects with complementary mutations in both copies of the gene and is associated with heavy bleeding in certain typical situations (e.g. when the umbilical cord is shed). It is also associated with extensive subcutaneous, intramuscular and intracerebral bleeding and hematoma without hemarthrosis. Such bleeding is characteristically delayed for several hours after the causative trauma. Abnormal wound healing has also been reported in subjects with this deficiency.Deficiency may be acquired in the form of anti-Factor XIII antibodies which are sometimes found in Schönlein's purpura, acute promyelocytic leukemia and diffuse intravascular coagulation.

Preanalytics

• 1 mL :
• Citrated Plasma
•   FROZEN
• Freezing within 4 hours

• A tube specifically for this analysis : Yes

Further information

Enclose the specific clinical information form (R5-INTGB : Haemostasis)
1 individual aliquot for this analysis.
It is advisable to send us a frozen and centrifuged citrate sample in compliance with the GFHT pre-analytical recommendations.

Methodology

Chromogenic method

Turnaround time

1 week