Eurofins Biomnis code

FAC8

Synonyms

• Antihaemophilic A - factor
• Antihaemophilic factor A

Specialty

Haematology

Clinical significance

Congenital factor VIII deficiency is responsible for haemophilia A. The transmission of haemophilia is recessive, related to sex. The severity of the disease is directly linked to levels of factor VIII in the bloodstream. Haemophilia is severe for levels <1%. Haemophilia is said to be moderate for levels 1-5% and minor for a level of factor VIII > 5%. The levels of factor VIII are also reduced in von Willebrand disease (see von Willebrand factor). An acquired reduction in factor VIII may result from the existence of an anti-factor VIII antibody (acquired haemophilia A), in the context of an autoimmune pathology for example. Several factors are likely to cause an increase in factor VIII: pregnancy, oral contraceptives, stress, inflammation, etc.

Preanalytics

• 2 mL :
• Citrated Plasma
•   FROZEN
• Freezing within 4 hours

• A tube specifically for this analysis : No

Further information

Enclose the specific clinical information form (R5-INTGB : Haemostasis)
Single tube possible for VIII, IX, XI,XII
The factors VIII, IX, XI,XII (aPTT factors) assay requires at least 2 mL of citrated plasma frozen.
Attach the clinical data relating to the patient (major inflammatory syndrome, pregnancy, etc.) and the circumstances (bleeding, thrombosis, preoperative evaluation, etc.)
It is advisable to send us a frozen and centrifuged citrate sample in compliance with the GFHT pre-analytical recommendations.

Documents to download

• Specific clinical information form (R5-INTGB)

Methodology

Chronometric method

Turnaround time

1 day