Factor I - Fibrinogen - activity - plasma
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FIBRI
Synonyms
- Fibrinogen - functional
- [To be translated]
Specialty
Haematology
Clinical significance
Fibrinogen is a glycoprotein synthesised in the liver and by megakaryocytes. Increased levels are associated with inflammation, diabetes, obesity, pregnancy, etc.. Levels can fall in diffuse intravascular coagulation. Congenital afibrinogenaemia is very unusual but there are patients with hypofibrinogenaemia who are prone to haemorrhage (the severity of the bleeding symptoms is directly related to the plasma concentration of fibrinogen). Defective fibrinogen (inherited) may be suspected when a normal or nearly normal absolute fibrinogen concentration is measured in a patient whose blood takes longer than normal to clot. Bleeding symptoms (usually minor) and sometimes a tendency to thrombosis may be associated with defective fibrinogen.
Preanalytics
- 2 mL :
- Citrated Plasma
- FROZEN
- Freezing within 4 hours
- A tube specifically for this analysis : No
Further information
Enclose the specific clinical information form (R5-INTGB : Haemostasis)
It is advisable to send us a frozen and centrifuged citrate sample in compliance with the GFHT pre-analytical recommendations.
Documents to download
Methodology
Chronometric method
Turnaround time
1 day