Eurofins Biomnis code

G6PD

Synonyms

• Glucose-6 phosphate dehydrogenase
• G6PD

Specialty

Biochemistry

Clinical significance

G6PD-deficiency is the most common erythrocyte enzyme deficiency. The G6PD gene is located on the X chromosome but the majority of hemizygous males are asymptomatic most of the time. However, a range of different clinical manifestations can be induced by a toxic or infectious insult. Acute hemolytic anemia can be induced by certain drugs or by the ingestion of a toxin. Fava beans, in particular are toxic for G6PD-deficient subjects, inducing severe hemolytic anemia (this predisposition is called favism). Similarly, certain infections (including infectious mononucleosis and viral hepatitis) can induce hemolytic anemia in such subjects. Heterozygous females are usually completely asymptomatic.

Preanalytics

• 2 mL :
• Whole blood EDTA excusively
•   Reftrigerated

• A tube specifically for this analysis : No

Further information

The dosage must imperatively be carried out at a distance from a blood transfusion (> 3 months).
Specify the FBC results: red blood cells and haemoglobin

Methodology

Enzymatic method

Turnaround time

2 days