Gentamicine - serum
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GENT
Synonyms
- Datamcine
- Gentalline
- Gentalline®
Specialty
Analytical Chemistry
Clinical significance
Gentamycin is a bactericidal aminoside antibiotic which inhibits bacterial protein synthesis by binding to ribosomes. Its natural antibacterial spectrum covers: Gram-negative and Gram-positive bacteria, including Staphylococci. It must be administered parenterally (IV or IM). It is eliminated via the kidneys with 100% clearance in new-borns and babies within 8 hours (as long as kidney function is normal). It can cause renal and cochleovestibular toxicity at plasma concentrations well above the normal therapeutic range. Its therapeutic index is relatively narrow so monitoring residual levels and peak plasma concentrations is important. Residual levels show whether or not there is any accumulation of the drug in the kidneys or the inner ear. The peak concentration immediately after administration can be used to gauge the bactericidal efficacy of the dose administered. Timing for drawing blood: - residual level: just before administration; - post-injection peak concentration: 1 hour after IM injection or 30 minutes after IV perfusion
Further information
Enclose the specific clinical information form (R18-INTGB : Infectious agents)
1 specific aliquot for this analysis
Residual level = before injection; Peak = 30 min after end of infusion or 1 hr after IM injection
Documents to download
Methodology
PETINIA immunoturbidimetric technique
Turnaround time
1 day
Biomnis Ivry
