Eurofins Biomnis code

HBCM

Synonyms

• .
• Anti-HBc IgG antibodies
• HBc - IgM antibodies
• HBV - Anti-HBc IgM antibodies
• HBV - anti-HBc IgM antibodies

Specialty

Infectious

Clinical significance

Hepatitis B is an acute or fulminant infection of the liver parenchyma, but can also be minor and inapparent and become chronic to develop cirrhosis or liver cancer. Widespread throughout the world, it is due to an enveloped DNA virus (Hepadnaviridae) that cannot be cultured. Hepatitis B diagnostics and follow-up combine complementary serological and molecular tests. Immunological tests study several viral antigen systems and the antibodies induced. Molecular tests (viral DNA detection and quantitification) study in more detail the degree of HBV replication and therefore the stage of the infection. Anti-HBc IgM antibodies, directed against viral core components, specifically mark acute hepatitis B. They appear 2 weeks after HBs antigen and persist for 3 to 7 months or more if ultrasensitive detection is used. They may be the only indication of recent infection when the HBs antigen has already disappeared. Anti-HBc IgG antibodies are present from the 3rd-4th month, they progressively replace the corresponding IgM and persist for a long time, even for life; they may be the only marker of previous infection. They are never detected after immunization, unless it was carried out on a subject previously contaminated with HBV.

Preanalytics

• 1 mL :
• serum
•   Reftrigerated

• A tube specifically for this analysis : No

Methodology

EIA

Turnaround time

2 days