Papillomavirus - HPV Détection and Typing of 19 high-risk HPV and 18 low-risk HPV - PCR

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Eurofins Biomnis code

HPVBM

Synonyms
  • cancer ORL HPV induit
  • Condylomes
  • HPV
  • Papillomavirus
Specialty

Infectious

Clinical significance

Human papillomaviruses (HPV) are DNA viruses responsible for sexually transmitted infections. Infection occurs through direct contact with lesions containing the virus during sexual intercourse, where the genitals and anus come into contact. The virus can also remain latent for a long time in the body following past contamination, and then reactivate. There are more than 110 genotypes of human HPV, with 16, 18, 45 and 56 being at high risk of oncogenicity. In the majority of cases, HPVs are responsible for anogenital condylomas, essentially of low-risk oncogenic genotypes (especially 6 and 11, more rarely 42, 43, etc.), or even higher-risk oncogenic genotypes (16, 18). Certain high-risk HPV genotypes can cause genital and ENT cancers. HPV test results must be interpreted in the light of the clinical and biological context. There are currently no expert recommendations for anogenital condyloma screening, or even for sperm testing. The diagnostic strategy for HPV-induced ENT cancer is different. A sample (biopsy) is required to confirm that the cancerous lesion is HPV-related. Furthermore, there is no interest in looking for oropharyngeal HPV infection in the spouse/partner. The HPV PCR test on a biopsy or mucocutaneous sample identifies 19 high-risk HPV and 18 low-risk HPV. High-risk HPV: HPV16, HPV18, HPV26, HPV31, HPV33, HPV35, HPV39, HPV45, HPV51, HPV52, HPV53, HPV56, HPV58, HPV59, HPV66, HPV68, HPV69, HPV73, HPV82 Low-risk HPVs: HPV6, HPV11, HPV40, HPV42, HPV43, HPV44, HPV54, HPV61, HPV62, HPV67, HPV70, HPV71, HPV72, HPV74, HPV81, HPV83, HPV84, HPV91

Preanalytics
  •  :
  • Skin or mucous membrane biopsy, 1 ml laryngeal sample, Oropharyngeal sample, genital sample (endocervix, ureter) or 1 ml urine, 1 ml sperm, anal
  •   Reftrigerated
  • A tube specifically for this analysis : No
Further information

[To be translated]
Biopsies should be placed as they are, in a dry tube and
The use of the S14UK transport bag is Mandatory.
Swab samples require the use of a transport medium (viral) supplied in kit K1.
Samples (other than swabs) must be sent as they are, in sterile bottles, without transport medium.

Specific equipment available
  • S14: Special mycobacteria transport bags are to be used
Documents to download
Methodology

[To be translated]

Turnaround time

8 days

Testing Laboratory

Contact(s)
Customer Care