Eurofins Biomnis code

HV6BM

Synonyms

• HHV-6 - molecular diagnosis
• HHV-6 - PCR

Specialty

Infectious

Clinical significance

HHV6 belongs to the Herpesviridae family. Primary infection is very common, occurring in the first few years of life. It is usually asymptomatic, or takes the form of maculopapular erythema (sudden exanthema of infants, roseola). Diagnosis is based on clinical findings. PCR testing for the HHV6 genome is reserved for atypical or complicated forms. HHV6 can cause serious local or disseminated infections (encephalitis, meningitis, hepatitis, retinitis or colitis). These complications generally arise in a context of immunodepression. This virus is also implicated in DRESS syndrome. HHV6 is unique in its ability to integrate into the human genome. This is a confounding factor in the interpretation of viral load. Any high viral load should suggest integration, especially if it persists. Proof of integration is provided by the presence of DNA in the phanera (nails, hair follicles).

Preanalytics

• 1 mL :
• Bronchial aspirations, BAL, bone marrow (EDTA), aqueous humor, CSF: qualitative result
•   Reftrigerated

• A tube specifically for this analysis : No

Further information

[To be translated]
Swabs require the use of a (viral) transport medium; Other specimens must be sent as such, in a sterile vial, without transport medium
The use of the S14UK transport bag is Mandatory.

Specific equipment available

• S14: Special mycobacteria transport bags are to be used

Documents to download

• information note (N23-INTGB)

Methodology

Real-time PCR

Turnaround time

6 days