Eurofins Biomnis code

HV6Q

Synonyms

• HHV6

Specialty

Infectious

Clinical significance

HHV6 belongs to the Herpesviridae family. Primary infection is very common, occurring in the first few years of life. It is usually asymptomatic, or takes the form of maculopapular erythema (sudden exanthema of infants, roseola). Diagnosis is based on clinical findings. PCR testing for the HHV6 genome is reserved for atypical or complicated forms. HHV6 can cause serious local or disseminated infections (encephalitis, meningitis, hepatitis, retinitis or colitis). These complications generally arise in a context of immunodepression. This virus is also implicated in DRESS syndrome. HHV6 is unique in its ability to integrate into the human genome. This is a confounding factor in the interpretation of viral load. Any high viral load should suggest integration, especially if it persists. Proof of integration is provided by the presence of DNA in the phanera (nails, hair follicles).

Preanalytics

• 1 mL :
• Whole blood (EDTA): quantitative result
•   Reftrigerated

• A tube specifically for this analysis : No

Further information

The use of the S14UK transport bag is Mandatory.

Documents to download

• information note (N23-INTGB)

Methodology

Real-time PCR

Turnaround time

6 days