Eurofins Biomnis code

ICK

Synonyms

• CK-BB - isoenzymes
• CK-MM - isoenzymes
• CPK isoenzymes
• Creatine phosphokinase - isoenzymes
• Macro-CK
• MacroCK

Specialty

Biochemistry

Clinical significance

Creatine kinase (CK) occurs as three isoenzymes based on dimeric combinations of two different polypeptides, i.e. the M (for muscle) and B (for brain) polypeptides. The isoenzymes - CK1 (BB), CK2 (MB) and CK3 (MM) - are found in different proportions in different tissues. CK BB increases in neurological disease, cancers affecting the digestive tract and after prostatectomy; CK MB levels can rise in myopathy, hypothyroidism, polymyositis and rhabdomyolysis or following physical injury or intramuscular injection. CK can bind immunoglobulin molecules to form macroenzymes and if a CK MB assay gives strange results, it may be due to the presence of such type 1 macro-CK. It is not possible to link type 1 macro-CK with any specific pathology but type 2 macro-CK has been shown to be associated with neoplasia in adults and is considered as an indicator of advanced tumor growth. Enzyme activity can increase significantly with exercise and varies between different ethnic groups.

Preanalytics

• 2 mL :
• serum (do not use 10 mL tube)
•   Reftrigerated

• A tube specifically for this analysis : No

Further information

Not to to be performed on haemolysed sample

Methodology

Electrophoresis

Turnaround time

7 days