Eurofins Biomnis code

IGE

Synonyms

• PRIST
• RIST

Specialty

Allergy

Clinical significance

The best characterized activity of IgE is in allergic responses in which antibodies of this class are bound to high affinity receptors on mast cells, basophils and Langerhans cells. When cells thus sensitized encounter the allergen in question, they are stimulated to release pre-formed mediators and synthesize other effector molecules leading to the clinical manifestations of allergy. Lower affinity IgE Fc receptors are found on many other cell types (including lymphocytes, eosinophils and platelets) and the binding of these receptors contributes to the development of the inflammatory response and to immune defense mechanisms against invading parasites. Total IgE levels correlate with allergy in 70% of cases. Increased IgE levels can also be seen in certain other situations, including:- parasitic infection;- viral infection;- certain forms of immunodeficiency;- hyperimmunoglobulinemia E syndrome.

Preanalytics

• 1 x 1 mL :
• serum
•   Reftrigerated

• A tube specifically for this analysis : No

Further information

ATTENTION: interference possible in patients treated with biotin (vitamin B7, B8 or H) or taking any food supplement containing biotin. Essential to STOP treatment 8 days before taking the sample.

Methodology

Electrochemiluminescence

Turnaround time

1 day