Eurofins Biomnis code

IGG4

Synonyms

• IgG4
• IgG4 subclasses

Specialty

Haematology

Clinical significance

The IgG4 sub-class represents 0 to 15% of total IgG. The relative proportions of the different sub-classes vary with age. Adult IgG4 concentrations are sometimes not reached until after 15 years of age.The Fc portion of the IgG4 molecule can bind to basophils and this sub-class seems to be involved in the phenomenon of desensitization because these antibodies appear following effective immunotherapeutic treatment of allergic patients.Autoantibodies can be of any of the four sub-classes. IgG4-related disease is a clinical condition often associated with a rise in serum IgG4 levels to more than 1.35 g/l. The main organs involved are: the pancreas (type 1 autoimmune pancreatitis) and the bile ducts, salivary and lachrymal glands, the mediastinal ganglia, the retroperitoneal space, aorta, lungs and kidneys.

Preanalytics

• 2 mL :
• serum
•   Reftrigerated

• A tube specifically for this analysis : No

Further information

ALWAYS specify the patient's age and gender

Methodology

Immuno turbidimetry

Turnaround time

1 day