Eurofins Biomnis code

MOHC2

Synonyms

• Acquired FISH
• acquired molecular cytogenetics

Specialty

Genetics

Clinical significance

Probes Blood : - 1p19q - 1p1q - 20q - BCL6 - BCR/ABL - CBFB - CEP7/7q - CEPX/Y - cMYC - EGR1 - ETV6/RUNX1 (TEL/AML1) - EVI1 (MECOM) - FGFR1/CEP8 - FIP1L1/PDGFRA - IGH DC - IGH/BCL2 - IGH/CCND1 - IGH/FGFR3 - IGH/MAF - Kit LLC : TP53, ATM, CEP12, 13q - MALT1 - MLL(KMT2A) - nMYC - NUP98 - P16/CEP9 - PDGFRB - PML/RARA - RARA DC - RUNX1/RUNX1T1 (ETO/AML1) - TCF3/PBX1 - TCRA/D - TP53/CEP17

Preanalytics

• 5 ml Heparinised whole blood, 2 ml Bone marrow, Lymph nodes
•   Ambient temperature

• A tube specifically for this analysis : No

Further information

Bone marrow: 1 heparinised syringe or medullary puncture transferred into a lithium heparinate tube ,Lymph node: sterile bottle
Cytogenetic study in the context of Myeloma: must be performed on bone marrow (not on peripheral blood). Exception: Plasma cell leukaemia: peripheral blood or bone marrow.
ALWAYS attach:
-The clinical and therapeutic details, full blood count results, platelets levels
The bone marrow report
Immunophenotyping report
The result of the Karyotype performed at the diagnostic step if not performed in Biomnis

Specific equipment available

• S9L: Envelopes yellow for karyotypes LYON

Documents to download

• Specific request form B8-INTGB
• DS2-INTFR - Pathological diagnosis and follow up of patients with Chronic Myeloid Neoplasms
• DS3 -INTGB - Acute leukemia
• DS62- Mature lymphoid noeplasm

Methodology

Molecular cytogenetics or FISH

Turnaround time

2 weeks if isolated FISH request, otherwise according to indication (AL: 1 week, MPD and MDS: 2 weeks, NHL and myeloma: 3 weeks)