Eurofins Biomnis code

PC

Synonyms

• Amidolytic protein C assay
• PC activity
• protein C
• Protein C activity
• Protein C anticoagulant activity

Specialty

Haematology

Clinical significance

Protein C (PC) is a vitamin K-dependent plasma protein which is synthesized in the liver. It is a physiological inhibitor of the coagulation cascade which, together with Protein S, cleaves the activated forms of Factors V and VIII. PC also promotes fibrinolysis by activating Plasminogen Activator Inhibitor (PAI).PC levels can rise in a variety of circumstances, including pregnancy, coronary heart disease, diabetes, nephrotic syndrome and in patients taking oral contraceptives.The main purpose of testing for inhibitors of coagulation is to detect congenital deficiency. Congenital PC deficiency can be either qualitative or quantitative with autosomal dominant or autosomal recessive transmission. Congenital PC deficiency is more common than congenital antithrombin III deficiency and is associated with venous thrombosis, thromboembolism and, less commonly, arterial thrombosis.Measuring the absolute PC level defines the kind of deficiency involved.

Preanalytics

• 2 mL :
• Citrated Plasma
•   FROZEN
• Freezing within 4 hours

• A tube specifically for this analysis : No

Further information

Enclose the specific clinical information form (R5-INTGB : Haemostasis)
PC and PS are vitamin K dependant and testing must be perform well after any AVK treatment (1 month)
Attach the clinical information concerning the patient (significant inflammation, pregnancy, family history, etc.) and the clinical context (bleeding, thrombosis, preoperative assessment, etc.)
It is advisable to send us a frozen and centrifuged citrate sample in compliance with the GFHT pre-analytical recommendations.

Documents to download

• Specific clinical information form (R5-INTGB)

Methodology

Chromogenic method

Turnaround time

1 day