Eurofins Biomnis code

PCAG

Synonyms

• PC Ag
• Protein C antigen

Specialty

Haematology

Clinical significance

Protein C (PC) is a vitamin K-dependent plasma protein which is synthesized in the liver. It is a physiological inhibitor of the coagulation cascade which, together with Protein S, cleaves the activated forms of Factors V and VIII. PC also promotes fibrinolysis by activating Plasminogen Activator Inhibitor (PAI).PC levels can rise in a variety of circumstances, including pregnancy, coronary heart disease, diabetes, nephrotic syndrome and in patients taking oral contraceptives.The main purpose of testing for inhibitors of coagulation is to detect congenital deficiency. Congenital PC deficiency can be either qualitative or quantitative with autosomal dominant or autosomal recessive transmission. Congenital PC deficiency is more common than congenital antithrombin III deficiency and is associated with venous thrombosis, thromboembolism and, less commonly, arterial thrombosis.Low PC levels may occur in new-borns, in patients with liver disease or in diffuse intravascular coagulation.

Preanalytics

• 1 mL :
• Citrated Plasma
•   FROZEN
• Freezing within 4 hours

• A tube specifically for this analysis : Yes

Further information

Enclose the specific clinical information form (R5-INTGB : Haemostasis)
1 individual aliquot for this analysis.
ALWAYS specify the current anticoagulant treatment
Attach the clinical data relating to the patient (major inflammatory syndrome, pregnancy, etc.) and the circumstances (bleeding, thrombosis, preoperative evaluation, etc.)
It is advisable to send us a frozen and centrifuged citrate sample in compliance with the GFHT pre-analytical recommendations.

Documents to download

• Specific clinical information form (R5-INTGB)

Methodology

Enzyme-immunoassay

Turnaround time

5 days