Eurofins Biomnis code

PECLA

Synonyms

• PIGF
• Pre-eclampsia
• Pre-eclampsia risk calculation

Specialty

Down Syndrome screening and foetal biochemistry

Clinical significance

PlGF (Placental Growth Factor) is, together with PAPP-A, a biochemical marker for pre-eclampsia. Assays are performed during the first trimester of pregnancy. It is possible to calculate an risk of early-onset (before 34 weeks of gestation) or late-onset pre-eclampsia (before 37 SA). This calculation of risk includes data about the patient (BMI, smoker/non-smoker, geographic origin, etc.) the history (number of viable pregnancies, history of pre-eclampsia, hypertension) and pregnancy underway (dating: date of the ultrasound and craniocaudal length) in addition to blood pressure and Doppler of uterine arteries.

Preanalytics

• 3 mL :
• Serum (1 specific tube for pre-eclampsia screening)
•   Refrigerated

• A tube specifically for this analysis : No

Further information

Enclose the specific clinical information form (R4-INTGB: Pre-eclampsia)
Risk assessment is possible for monofoetal pregnancies only
Sample must be collected between 11.0 and 13.6 weeks of amenorrhoea
Non hemolysed, non-icteric, non lipemic sample. Sample must be centrifuged as quickly as possible and international samples must be frozen within 4 hours of sampling; except for Switzerland, Luxembourg and Belgium (REFRIGERATED)
Please conserve an additional sample in your serolibrary until you have received the result.
Arterial blood pressure should be taken on both arms at the same time; if not, a single arm will suffice.
The period between the ultrasound scan, the taking of blood pressure and sample collection
must not exceed 10 days.

Specific equipment available

• [To be translated]

Documents to download

• Specific clinical information form (R4-INTGB)

Methodology

Fluoro-Immunoassay (time resolved)

Turnaround time

1 week