Eurofins Biomnis code

PR3

Synonyms

• Anti-proteinase 3 antibodies
• Proteinase 3 - anti-antibodies
• PR3 - anti-antibodies
• [To be translated]

Specialty

Immunology

Clinical significance

A recently developed marker which is very useful in the diagnosis of vasculitis. Three different staining patterns can be distinguished on polymorphonuclear cells fixed in ethanol and formaldehyde: cytoplasmic, perinuclear and X-ANCA. The two main specificities (myeloperoxidase and proteinase 3) can be typed by Flow immunofluorometry. Perinuclear staining due to antinuclear antibodies can interfere with this screen.The presence of anti-PR3 antibodies correlates strongly with Wegener's granulomatosis whereas anti-MPO antibodies are found in crescentic glomerulonephritis and Shurg-Strauss syndrome (although this is less specific).

Preanalytics

• 2 mL :
• Sérum
•   Reftrigerated

• A tube specifically for this analysis : No

Methodology

EliA (Fluoro-Enzymoimmunologie)

Turnaround time

3 days